This is HaikaLab
We study primary immuno-oncology (IO) and targeted therapy resistance mechanisms & aim to discover more durable immuno- and targeted therapy combinations for lung cancer patients
Lab Members
Meet our brilliant scientists 🔬
Heidi Haikala, PhD,
Principal Investigator,
Assistant Professor
"I did my PhD in the University of Helsinki, after which I worked as a postdoc in Dana-Farber Cancer Institute & Harvard Medical School in Prof. Pasi Jänne's Lab. In DFCI, I developed new targeted therapy strategies to prevent EGFR inhibitor resistance in lung cancer.
One of our findings led to a clinical trial in lung cancer patients.
Our group studies how to target primary (immuno)therapy resistance and discovers new combination therapies for lung cancer.
Science communication, music, yoga & winter sports are close to my heart! "
Bassel Alsaed,
MSc,
PhD Researcher
(Immuno-oncology & ex vivo models)
" I'm studying immunotherapy resistance in lung cancer using 3D co-cultures. This includes culturing patient-derived organoids with matched T cells with or without immunotherapies (e.g., checkpoint inhibitors). The aim of the study is to figure out new mechanisms of immunotherapy resistance and optimize an easy-to-use screening platform for patient-derived tissues.
I also like (all) good food, especially the swedish semla!"
Elena Kremneva, PhD,
Research Coordinator
(Tumor-on-chip)
"I did my PhD in A.N. Bach Institute of Biochemistry, after which I worked as postdoctoral researcher in Neuroscience Centre & Institute of Biotechnology at University of Helsinki. My research focused on actin-binding proteins and maintenance of actin cytoskeleton. Now I work on developing a new tumor-on-a-chip platform that could be used for studying individual drug responses in cancer patients. Solving problems and setting up new methods are of my interest. Outside work, I enjoy reading, walking and spending time with my family."
Lilja Lahtinen,
MSc,
Research Assistant
(Patient samples/ Drug screening)
"I did my master’s degree in neuroscience at the University of Helsinki. My job in the lab is to process patient-derived tumor samples and use them to culture 3D organoids. I maintain our cell lines and prepare them for DNA sequencing, co-culture experiments, and more. In my free time you can often find me baking, playing music, or enjoying the outdoors!"
Johannes Smolander, PhD, Postdoctoral Researcher (Bioinformatics)
"I did my PhD at the University of Turku, the topic of which was scRNA-seq analysis. I am interested in everything related to NGS analysis, and especially its applications related to immunology. In my spare time, I do a variety of sports and play video games."
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Milos Gojkovic,
PhD,
Postdoctoral
Researcher
(Immunology)
"I completed my PhD at Karolinska Institutet, where I studied oxygen sensing in myeloid cells and its implications for physiology and cancer. I then pursued postdoctoral research at the University of Cologne, focusing on cell death and inflammation, particularly within the context of immune responses. Currently, my research is centered on discovering novel blood-based biomarkers to optimize immuno-oncology treatments for lung cancer. In my free time, I enjoy photography, spending time outdoors, and being with my family and friends."
Linh Lin,
MSc,
PhD Researcher
(New therapeutics)
"I completed my Master’s degree in Genetics and Molecular Biosciences in the University of Helsinki, specializing in Molecular and Analytical Health Biosciences. I gained interest in translational medicine during my studies.
In the lab I study the epigenetic and protein level regulators of EGFR expression in lung cancer, by using CRISPR and other genetic screening methods.
Dancing, reading and eating delicious food are my favorite activities!"
💃🏻📚🍽
Hanna Laitinen, MSc,
PhD Researcher
(Innate immunity)
"I have completed my Master's thesis in Molecular Medicine at the University of Eastern Finland and have previously studied lung cancer using 2D in vitro -models. Now, I'm participating in immunotherapy resistance study in which we use patient-derived 3D co-cultures. In addition, I'm helping with other work in the lab. In my free time you can find me doing a variety of different sports, reading, or photographing the nature."
Narges Moradi,
MSc,
PhD Researcher
(Emerging immunotherapeutics)
"I did my MSc in Molecular Biotechnology, at the University of Turku. Following that, I explored the fascinating world of oncology research, contributing to both the Antibody Drug Conjugates (ADCs) and Cancer Genomics teams at Orion Pharma.
Currently, I am on an exciting journey pursuing my PhD at the HaikaLab. My research focuses on unraveling the tumor-specific immunological properties and immunopeptidome in lung cancer. My ultimate goal is to pave the way for novel immuno-oncological therapeutics in lung cancer or enhance the effectiveness of existing ones. Outside the lab, I like to read , write , do yoga , and travel."
Kasim Kaader,
MD/PhD Researcher
(Immunotherapy resistance)
"I completed my Bsc in Medicine at the University of Helsinki. I am interested in working together with other people to find good answers to good questions, and I currently pursue a PhD in the field of immuno-oncology. For my PhD project, we aim to find pharmacologically targetable biomarkers for IO resistance. Apart from medicine and science, I enjoy playing the clarinet and playing tennis."
Elenia Bracalenti,
PhD Researcher
(Immune development
& cancer)
"I am a student of the Master’s in Molecular and Medical Biotechnology in Verona (Italy). After training in different labs in the Institute of Biotechnology at the University of Helsinki, I chose HaikaLab to focus on personalized medicine and immuno-oncology. For my Master’s thesis project, I worked on a genome-wide CRISPR screening in combination with NK cells. I just started my PhD studying the relationship of immune system development and lung cancer.
In my free time, I like working out, dancing, and traveling around the world."
Iina Kaisaniemi,
BSc,
MSc Student
(Cancer-associated fibroblasts)
"I did my Bachelor‘s degree in molecular biosciences at the University of Helsinki and wrote my thesis about modeling lungs and lung cancer using 3D models. I will continue my studies in Genetics and Molecular Bioscienses master’s program. In the lab I’m investigating the role of cancer-associated fibroblasts in responses to different treatments. In my free time I enjoy yoga, going to the gym and taking walks by the sea."
Zac Darroch,
BSc,
Research Assistant (Bioanalytics)
"I did my Bachelor of Biomedical Science at Newcastle University in Australia, with my undergraduate thesis at the Karolinska Institutet in Stockholm. After this I worked for seven years as a Hospital Scientist in Clinical Chemistry at the Royal Prince Alfred Hospital in Sydney before moving to Finland. In my free time I enjoy hiking, reading history, trivia and playing social football. A thirst for fresh experiences has taken me to many places, from climbing Kilimanjaro and kayaking the White Nile to driving from London to Mongolia via Kyrgyzstan. These days however you are more likely to find me on the weekends exploring the playgrounds of Espoo with my kids."
Shadi Jansouz, MSc,
Research Assistant
(Patient samples & 3D culture)
”I did my master's degree in medical biotechnologies at the University of Siena in Italy. My job as laboratory coordinator is to process patient-derived tumor samples into 3D organoid cultures, operate molecular and histological procedures both from tissues and established 3D cells-lines, as well as preparations and plannings for different experiments at lab.
In my free time you can find me working out at gym, dancing tango, and listening to podcasts."
💃🏻
Jenna Ilomäki
BSc,
Research Assistant
(Laboratory engineer / analyst)
"I did my Bachelor of Laboratory services and Laboratory Engineering at Tampere University of Applied Sciences. After my thesis I have over ten years of work experience as a Research Assistant from diabetes and tuberculosis research. My job is mostly maintenance and setting up new protocols for our laboratory in Tampere. In my fee time I like knitting and crocheting. Sometimes I forget time when I do jigsaw puzzles.
I also like to dance!"
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